Autologous skeletal myoblasts transduced with a new adenoviral bicistronic vector for treatment of hind limb ischemia
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چکیده
منابع مشابه
LATE EMBOLECTOMY FOR LIMB OR KNEE SALVAGE IN ACUTE LOWER LIMB ISCHEMIA: A NEW PROTOCOL
Embolectomy has long been the gold standard for treating limbs acutely threatened by arterial occlusion. Delayed embolectomy has not been investigated adequately due to the belief that accompanying mortality and morbidity render the case futile. Following our previous experience with late arterial repair for leg or knee salvage I we applied the same principle to limbs threatened with prolo...
متن کاملTime course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice.
DNA microarrays were used to measure the time course of gene expression during skeletal muscle damage and regeneration in mice following femoral artery ligation (FAL). We found 1,289 known sequences were differentially expressed between the FAL and control groups. Gene expression peaked on day 3, and the functional cluster "inflammation" contained the greatest number of genes. Muscle function w...
متن کاملThe role of osteopontin in recovery from hind limb ischemia.
OBJECTIVE Osteopontin (OPN) is a highly phosphorylated extracellular matrix glycoprotein that is involved in a diversity of biological processes. In the vascular wall, OPN is produced by monocytes/macrophages, endothelial cells, and smooth muscle cells, and it is thought to mediate adhesion, migration, and survival of these cell types. In this study, we hypothesized that OPN plays a critical ro...
متن کاملFACS-purified myoblasts producing controlled VEGF levels induce safe and stable angiogenesis in chronic hind limb ischemia
We recently developed a method to control the in vivo distribution of vascular endothelial growth factor (VEGF) by high throughput Fluorescence-Activated Cell Sorting (FACS) purification of transduced progenitors such that they homogeneously express specific VEGF levels. Here we investigated the long-term safety of this method in chronic hind limb ischemia in nude rats. Primary myoblasts were t...
متن کاملAutologous Myoblasts for the Treatment of Fecal Incontinence
OBJECTIVE The aim of this study was to evaluate the efficacy of intrasphincteric injections of autologous myoblasts (AMs) in fecal incontinence (FI) in a controlled study. SUMMARY OF BACKGROUND DATA Adult stem cell therapy is expected to definitively cure FI by regenerating damaged sphincter. Preclinical data and results of open-label trials suggest that myoblast therapy may represent a nonin...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2004
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2004.07.027